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Numerical evaluation of the transition probability of the simple birth-and-death process

The simple (linear) birth-and-death process is a widely used stochastic model for describing the dynamics of a population. When the process is observed discretely over time, despite the large amount of literature on the subject, little is known about …

Improving the consistency of functional genomics screens using molecular features - a multi-omics, pan-cancer study

Probing the genetic dependencies of cancer cells helps understand the tumor biology and identify potential drug targets. RNAi-based shRNA and CRISPR/Cas9-based sgRNA have been commonly utilized in functional genetic screens to identify essential …